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AI-1

Chemical Structure : AI-1

CAS No.: 75483-04-4

AI-1 (Nrf2 activator AI-1)

Catalog No.: PC-62429Not For Human Use, Lab Use Only.

Nrf2 activator AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM.

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Biological Activity

Nrf2 activator AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM.
Nrf2 activator AI-1 is an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.

Physicochemical Properties

M.Wt 265.69
Formula C13H12ClNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

References

1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47.

2. Large M, et al. Strahlenther Onkol. 2015 Sep;191(9):742-9.

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