| Cat. No. |
Product Name |
Information |
| PC-20065 |
S217879
NRF2 activator
|
S217879 (S 217879) is a highly potent and selective NRF2 activator, binds to KEAP1 Kelch domain (SPR Kd=4.15 nM), disrupts the KEAP1-NRF2 interaction leading to robust NRF2 pathway activation. |
| PC-47059 |
BC-1901S
NRF2 activator
|
BC-1901S is a potent small molecule NRF2 activator that stabilizes NRF2 and increases NRF2 activity, activates NRF2 by inhibiting NRF2 ubiquitination in a KEAP1-independent manner. |
| PC-38460 |
KI-696
KEAP1-NRF2 inhibitor
|
KI-696 (KI696) is a highly potent, selective inhibitor of KEAP1-NRF2 interaction, exhibits very high affinity for the KEAP1 Kelch domain with ITC Kd of 1.3 nM. |
| PC-73337 |
HPPE
Bach1 inhibitor
|
HPPE is a specific nonelectrophilic and physiological Bach1 inhibitor via heme-binding sites of Bach1 protein, derepresses Bach1-mediated repression. |
| PC-72862 |
PRL-295
Keap1-Nrf2 inhibitor
|
PRL-295 is a small molecule Keap1-Nrf2 protein-protein interaction inhibitor. |
| PC-38190 |
MSU38225
Nrf2 inhibitor
|
MSU38225 (MSU-38225) is a novel small molecule that inhibit the Nrf2 pathway, potentially inhibiting Nrf2 transcriptional activity and cancer cell growth. |
| PC-35259 |
Brusatol
Nrf2 inhibitor
|
Brusatol (NSC 172924, (+)-Brusatol) is a quassinoid extracted from Brucea Esters, can inhibit HIF-1 signaling pathway, also is a potent Nrf2 inhibitor. |
| PC-43494 |
CDDO Methyl ester
Nrf2 activator
|
CDDO Methyl ester (NSC 713200, RTA 402, Bardoxolone methyl, CDDO-Me) is a potent activator of Nrf2, inhibits proliferation, induces differentiation and apoptosis in AML cells. |
| PC-63001 |
Sulforaphane
Nrf2 activator
|
Sulforaphane (SFN) is an antioxidant agent that exerts protective effects against cell damage by activating Nrf2. |
| PC-62796 |
K67
Keap1-Nrf2 inhibitor inhibitor
|
K67 is a specific inhibitor of the interaction between S349-phosphorylated p62 and Keap1, exhibts no inhibitory effect on the interaction of full-length Keap1 with Nrf2-ETGE or full-length Nrf2. |
| PC-62795 |
Nrf2 activator 16
Nrf2 activator
|
Nrf2 activator 16 is a potent Keap1-Nrf2 and Keap1-p-p62 protein-protein interaction inhibitor with IC50 of 0.91 uM and 1.8 uM respectively. |
| PC-62575 |
QD325
Nrf2 activator
|
QD325 is a potent redox modulator that induces Nrf2-mediated oxidative stress and unfolded protein responses in PDAC cells (IC50=0.9 uM). |
