Chemical Structure : Keap1-Nrf2 inhibitor 6K
CAS No.:
2796292-75-4
Keap1-Nrf2 inhibitor 6K
Catalog No.: PC-28166Not For Human Use, Lab Use Only.
Keap1-Nrf2 inhibitor 6K is a small molecule inhibitor of Keap1-Nrf2 interaction, exhibits high Keap1-binding affinity (KD2 values=210 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Keap1-Nrf2 inhibitor 6K is a small molecule inhibitor of Keap1-Nrf2 interaction, exhibits high Keap1-binding affinity (KD2 values=210 nM).
Keap1-Nrf2 inhibitor 6K markedly improves renal function, suppresses OS and ferroptosis, and upregulates adaptive repair-related genes and downregulates maladaptive repair-related genes in bIRI mice.
Keap1-Nrf2 inhibitor 6K activated the Nrf2-GPX4 axis, thereby alleviated RSL3-induced suppression of GPX4 expression, reduced reactive oxygen species (ROS) accumulation and lipid peroxidation, and mitigated ferroptosis in human kidney-2 (HK-2) cells.
Keap1-Nrf2 inhibitor 6K significantly delayed fibrosis progression in bIRI and unilateral ureteral obstruction (UUO) models.
Physicochemical Properties
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M.Wt
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765.90
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Formula
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C36H43N7O8S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-(N-(2-amino-2-oxoethyl)-N-(4-((N-(2-amino-2-oxoethyl)-4-methoxyphenyl)sulfonamido)naphthalen-1-yl)sulfamoyl)phenyl)-3-(4-ethylpiperazin-1-yl)propanamide
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References
1. Wang Y, et al. Redox Biol. 2026 Sep 2;97:104374.
2. Liu G, et al. J Med Chem. 2022 Jun 23;65(12):8289-8302.
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