| Cat. No. |
Product Name |
Information |
| PC-42917 |
CDDO-EA
Nrf2 activator
|
CDDO-EA (DDO ethyl amide, RTA405) is a potent Nrf2 activator that upregulates Nrf2 expression and resulted in translocation of Nrf2 into the nucleus. |
| PC-42916 |
RTA-408
Nrf2 activator
|
RTA-408 (Omaveloxolone, RTA408) is a potent Nrf2 activator that increases expression of Nrf2 target genes and decreases expression of inflammatory mediators. |
| PC-44663 |
CDDO-Im
PPAR agonist, Nrf2 activator
|
CDDO-Im (RTA-403) is a potent Nrf2 activator that elevates protein levels of Nrf2 and induces Nrf2/ARE signaling, also activates PPAR with Ki values of 232 and 344 nM for PPARα and PPARγ. |
| PC-45198 |
Ezetimibe
Nrf2 activator, NPC1L1 inhibitor
|
Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules. |
| PC-42172 |
TBHQ
Nrf2 activator
|
TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo. |
| PC-42187 |
ML385
NRF2 inhibitor
|
ML385 is a first-in-class small molecule inhibitor of NRF2 that binds to Neh1 DNA binding domain of NRF2 (IC50=1.9 uM) and inhibits the downstream target gene expression. |
| PC-25023 |
Rosolutamide
Nrf1/ Nrf2 activator
|
Rosolutamide (ASC-JM17) is a curcumin analog, an orally active, potent Nrf1 and Nrf2 activator, activates Nrf1, Nrf2, and heat shock factor 1 (Hsf1), which in turn activates the expression of proteasome subunits, antioxidant enzymes, and molecular chaperones. |
| PC-24918 |
UD-051
Nrf2 activator
|
UD-051 is a potent Nrf2 activator and inhibitor of Kelch-like ECH-associated protein 1 (Keap1) and Nrf2 interaction, activates NQO1 in Hepa1c1c7 cells with EC50 of 0.36 nM. |
| PC-24870 |
Nrf2 agonist C5
Nrf2 agonist
|
Nrf2 agonist C5 is a novel chalcone-derived covalent Keap1 binder and Nrf2 agonist, strongly blocks Keap1-Nrf2 interaction and enhances Nrf2 stability. |
| PC-24785 |
CB5712809
Keap1 inhibitor
|
CB5712809 is a high affinity Keap1 inhibitor, inhibits Keap1:Nrf2 activity with IC50 of 36.7 nM. |
| PC-24727 |
CBR-470-1
PGK1 inhibitor, NRF2 activator
|
CBR-470-1 is a small molecule inhibitor of glycolytic enzyme phosphoglycerate kinase 1 (PGK1), activates NRF2 signaling in vitro and in vivo. |
| PC-24726 |
CBR-470-2
PGK1 inhibitor, NRF2 activator
|
CBR-470-2 is a small molecule inhibitor of glycolytic enzyme phosphoglycerate kinase 1 (PGK1), activates NRF2 signaling in vitro and in vivo. |
