| Cat. No. |
Product Name |
Information |
| PC-44663 |
CDDO-Im
PPAR agonist, Nrf2 activator
|
CDDO-Im (RTA-403) is a potent Nrf2 activator that elevates protein levels of Nrf2 and induces Nrf2/ARE signaling, also activates PPAR with Ki values of 232 and 344 nM for PPARα and PPARγ. |
| PC-45198 |
Ezetimibe
Nrf2 activator, NPC1L1 inhibitor
|
Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules. |
| PC-42172 |
TBHQ
Nrf2 activator
|
TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo. |
| PC-42187 |
ML385
NRF2 inhibitor
|
ML385 is a first-in-class small molecule inhibitor of NRF2 that binds to Neh1 DNA binding domain of NRF2 (IC50=1.9 uM) and inhibits the downstream target gene expression. |
| PC-22478 |
DDO-7263
Nrf2 activator
|
DDO-7263 is a a potent small molecule Nrf2-ARE activator, inhibits NLRP3 inflammasome activationand shows neuroprotective effect, upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome. |
| PC-22348 |
4-octyl itaconate
NRF2 activator
|
4-Octyl Itaconate (4-OI) is a cell-permeable Itaconate derivative, activates Nrf2 via alkylation of KEAP1, is protective against lipopolysaccharide-induced lethality in vivo and decreases cytokine production. |
| PC-21180 |
NRF2 inhibitor R16
NRF2 inhibitor
|
NRF2 inhibitor R16 is a novel mutated KEAP1 (mKEAP1)-selective NRF2 inhibitor, binds KEAP1-mutated proteins (G333C mKEAP1, Kd=2.7 uM) and restores their interaction with NRF2, leading to proteasome-dependent NRF2 degradation. |
| PC-21171 |
Spinosin
Nrf2/HO-1 activator
|
Spinosyn is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujube with neuroprotective effects, inhibits Aβ1-42 production and aggregation via activating Nrf2/HO-1 pathway. |
| PC-20558 |
Keap1-Nrf2 inhibitor 25
Keap1-Nrf2 inhibitor
|
Keap1-Nrf2 inhibitor 25 is a potent, orally bioavailable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with IC50 of 89 nM. |
| PC-73338 |
Cobalt protoporphyrin IX chloride
Bach1 inhibitor
|
Cobalt protoporphyrin IX (CoPPIX) is a potent and effective inducer of HO-1 (heme oxygenase-1) activity, up-regulates HO-1 via Bach1 and Nrf2 in human liver cells. |
