| Cat. No. |
Product Name |
Information |
| PC-42916 |
RTA-408
Nrf2 activator
|
RTA-408 (Omaveloxolone, RTA408) is a potent Nrf2 activator that increases expression of Nrf2 target genes and decreases expression of inflammatory mediators. |
| PC-44663 |
CDDO-Im
PPAR agonist, Nrf2 activator
|
CDDO-Im (RTA-403) is a potent Nrf2 activator that elevates protein levels of Nrf2 and induces Nrf2/ARE signaling, also activates PPAR with Ki values of 232 and 344 nM for PPARα and PPARγ. |
| PC-45198 |
Ezetimibe
Nrf2 activator, NPC1L1 inhibitor
|
Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules. |
| PC-42172 |
TBHQ
Nrf2 activator
|
TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo. |
| PC-42187 |
ML385
NRF2 inhibitor
|
ML385 is a first-in-class small molecule inhibitor of NRF2 that binds to Neh1 DNA binding domain of NRF2 (IC50=1.9 uM) and inhibits the downstream target gene expression. |
| PC-23226 |
Keap1-Nrf2 inhibitor 57
Keap1-Nrf2 inhibitor
|
Keap1-Nrf2 inhibitor 57 is a higly potent, noncovalent Keap1-Nrf2 inhibitor with Ki of 13 nM in FP assays, binds the Keap1 Kelch domain with excellent selectivity over close homologues from the Kelch-like protein family. |
| PC-22794 |
KCB-F06
Keap1-Nrf2 inhibitor
|
KCB-F06 is a small molecule Keap1-Nrf2 PPI inhibitor, inhibits RANKL-induced osteoclastogenesis in vitro and blocks OVX-mouse bone loss in vivo. |
| PC-22765 |
ML334
Keap1-Nrf2 inhibitor
|
ML334 (LH601A) is a cell permeable inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction (PPI) with ARE-inducing EC50 of 18 uM, promotes the nuclear translocation of Nrf2 with EC50 of 12 uM in Keap1-Nrf2 functional assay. |
| PC-22761 |
biKEAP1
KEAP1 inhibitor
|
biKEAP1 is a potent, unique bivalent inhibitor of BTB-containing E3 ligase KEAP1 dimer with ITC Kd of 10.4 nM, promotes the dimerization of KEAP1 and binds to KEAP1 in a bivalent fashion, instantly activates NRF2 by promoting the release of NRF2 from the KEAP1 dimer. |
| PC-22478 |
DDO-7263
Nrf2 activator
|
DDO-7263 is a a potent small molecule Nrf2-ARE activator, inhibits NLRP3 inflammasome activationand shows neuroprotective effect, upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome. |
| PC-22348 |
4-octyl itaconate
NRF2 activator
|
4-Octyl Itaconate (4-OI) is a cell-permeable Itaconate derivative, activates Nrf2 via alkylation of KEAP1, is protective against lipopolysaccharide-induced lethality in vivo and decreases cytokine production. |
| PC-21180 |
NRF2 inhibitor R16
NRF2 inhibitor
|
NRF2 inhibitor R16 is a novel mutated KEAP1 (mKEAP1)-selective NRF2 inhibitor, binds KEAP1-mutated proteins (G333C mKEAP1, Kd=2.7 uM) and restores their interaction with NRF2, leading to proteasome-dependent NRF2 degradation. |
