| Cat. No. |
Product Name |
Information |
| PC-45694 |
NK-252
Nrf2 activator
|
NK-252 (NK252) is a small molecule Nrf2 activator, exhibits a greater Nrf2-activating potential than oltipraz (OPZ). |
| PC-45182 |
Dimethyl fumarate
Nrf2 activator
|
Dimethyl fumarate (DMF, BG-12) exerts anti-inflammatory and pro-metabolic effects in a variety of cell types, activates the Nrf2 pathway. |
| PC-43044 |
14-3-3 inhibitor WS3
14-3-3 inhibitor, NRF2 inhibitor
|
14-3-3 inhibitor WS3 is a potent, allosteric inhibitor of 14-3-3 proteins, potently inhibits the NRF2-ARE signal with IC50 of 135 nM in A549 cells, selectively inhibits NRF2 activity in tumor cells. |
| PC-42917 |
CDDO-EA
Nrf2 activator
|
CDDO-EA (DDO ethyl amide, RTA405) is a potent Nrf2 activator that upregulates Nrf2 expression and resulted in translocation of Nrf2 into the nucleus. |
| PC-42916 |
RTA-408
Nrf2 activator
|
RTA-408 (Omaveloxolone, RTA408) is a potent Nrf2 activator that increases expression of Nrf2 target genes and decreases expression of inflammatory mediators. |
| PC-44663 |
CDDO-Im
PPAR agonist, Nrf2 activator
|
CDDO-Im (RTA-403) is a potent Nrf2 activator that elevates protein levels of Nrf2 and induces Nrf2/ARE signaling, also activates PPAR with Ki values of 232 and 344 nM for PPARα and PPARγ. |
| PC-45198 |
Ezetimibe
Nrf2 activator, NPC1L1 inhibitor
|
Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules. |
| PC-42172 |
TBHQ
Nrf2 activator
|
TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo. |
| PC-42187 |
ML385
NRF2 inhibitor
|
ML385 (ML-385) is a first-in-class small molecule inhibitor of NRF2 that binds to Neh1 DNA binding domain of NRF2 (IC50=1.9 uM) and inhibits the downstream target gene expression. |
| PC-27017 |
Keap1-p-p62-IN-2
Nrf2 inhibitor, Keap1-p-p62 inhibitor
|
Keap1-p-p62-IN-2 is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.096 uM, >6-fold selectivity over inhibition of Keap1-Nrf2 interaction. |
| PC-27016 |
Keap1-p-p62 inhibitor 13
Nrf2 inhibitor, Keap1-p-p62 inhibitor
|
Keap1-p-p62 inhibitor 13 (Keap1-p-p62-IN-1) is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.11 uM, high selectivity over inhibition of Keap1-Nrf2 interaction. |
| PC-26889 |
SLOS-1811-06 tR1
Nrf2 activator
|
SLOS-1811-06 tR1 is a potent, small molecule activator of NRF2 with EC50 of 0.98 nM in ARE-luciferase reporter assays, shows inhibitory activity of NRF2-KEAP1 with IC50 of 0.17 nM in BRET assays, protects hiPSC-derived RGCs from hypoxia/reoxygenation injury. |
