| Cat. No. |
Product Name |
Information |
| PC-45182 |
Dimethyl fumarate
Nrf2 activator
|
Dimethyl fumarate (DMF, BG-12) exerts anti-inflammatory and pro-metabolic effects in a variety of cell types, activates the Nrf2 pathway. |
| PC-43044 |
14-3-3 inhibitor WS3
14-3-3 inhibitor, NRF2 inhibitor
|
14-3-3 inhibitor WS3 is a potent, allosteric inhibitor of 14-3-3 proteins, potently inhibits the NRF2-ARE signal with IC50 of 135 nM in A549 cells, selectively inhibits NRF2 activity in tumor cells. |
| PC-42917 |
CDDO-EA
Nrf2 activator
|
CDDO-EA (DDO ethyl amide, RTA405) is a potent Nrf2 activator that upregulates Nrf2 expression and resulted in translocation of Nrf2 into the nucleus. |
| PC-42916 |
RTA-408
Nrf2 activator
|
RTA-408 (Omaveloxolone, RTA408) is a potent Nrf2 activator that increases expression of Nrf2 target genes and decreases expression of inflammatory mediators. |
| PC-44663 |
CDDO-Im
PPAR agonist, Nrf2 activator
|
CDDO-Im (RTA-403) is a potent Nrf2 activator that elevates protein levels of Nrf2 and induces Nrf2/ARE signaling, also activates PPAR with Ki values of 232 and 344 nM for PPARα and PPARγ. |
| PC-45198 |
Ezetimibe
Nrf2 activator, NPC1L1 inhibitor
|
Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules. |
| PC-42172 |
TBHQ
Nrf2 activator
|
TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo. |
| PC-42187 |
ML385
NRF2 inhibitor
|
ML385 (ML-385) is a first-in-class small molecule inhibitor of NRF2 that binds to Neh1 DNA binding domain of NRF2 (IC50=1.9 uM) and inhibits the downstream target gene expression. |
| PC-25485 |
VVD-065
NRF2 inhibitor, KEAP1-CUL3 molecular glue
|
VVD-065 is a first-in-class, allosteric molecular glue of Keap1-Cul3 E3-ligase complex and NRF2 inhibitor, specifically and covalently engages C151 on KEAP1 with engagement potency (TE50) of 9 nM in KYSE70 cells, promotes KEAP1-CUL3 complex formation, leading to enhancement of NRF2 degradation. |
| PC-25376 |
Keap1-Nrf2 inhibitor 28
Keap1-Nrf2 inhibitor
|
Keap1-Nrf2 inhibitor 28 is a high potent small molecule inhibitor of Keap1-Nrf2 with Ki of 8.8 nM, induces expression of NQO1 mRNA with EC50 of 60.1 nM in BEAS-2B cells with qPCR-based assays. |
| PC-25375 |
Keap1-Nrf2 inhibitor 24
Keap1-Nrf2 inhibitor
|
Keap1-Nrf2 inhibitor 24 is a high potent small molecule inhibitor of Keap1-Nrf2 with Ki of 10 nM, induces expression of NQO1 mRNA with EC50 of 110 nM in BEAS-2B cells with qPCR-based assays. |
| PC-25215 |
CDDO-TFEA
Nrf2 activator
|
CDDO-TFEA (RTA 404, TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier, an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. |
