| Cat. No. |
Product Name |
Information |
| PC-62795 |
Nrf2 activator 16
Nrf2 activator
|
Nrf2 activator 16 is a potent Keap1-Nrf2 and Keap1-p-p62 protein-protein interaction inhibitor with IC50 of 0.91 uM and 1.8 uM respectively. |
| PC-62575 |
QD325
Nrf2 activator
|
QD325 is a potent redox modulator that induces Nrf2-mediated oxidative stress and unfolded protein responses in PDAC cells (IC50=0.9 uM). |
| PC-62430 |
AI-2
Nrf2 activator
|
Nrf2 activator AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1. |
| PC-62429 |
AI-1
Nrf2 activator
|
Nrf2 activator AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM. |
| PC-62392 |
AEM1
Nrf2 inhibitor
|
NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC). |
| PC-70279 |
MIND4-17
Nrf2 activator
|
MIND4-17 is an inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM. |
| PC-60871 |
RA839
Nrf2 activator
|
RA839 is a noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling. |
| PC-60630 |
PSTC
Nrf2 activator
|
PSTC is a potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity). |
| PC-60016 |
BPK-29
NR0B1 inhibitor
|
BPK-29 (BPK29) is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells. |
| PC-45694 |
NK-252
Nrf2 activator
|
NK-252 (NK252) is a small molecule Nrf2 activator, exhibits a greater Nrf2-activating potential than oltipraz (OPZ). |
| PC-45182 |
Dimethyl fumarate
Nrf2 activator
|
Dimethyl fumarate (DMF, BG-12) exerts anti-inflammatory and pro-metabolic effects in a variety of cell types, activates the Nrf2 pathway. |
| PC-43044 |
14-3-3 inhibitor WS3
14-3-3 inhibitor, NRF2 inhibitor
|
14-3-3 inhibitor WS3 is a potent, allosteric inhibitor of 14-3-3 proteins, potently inhibits the NRF2-ARE signal with IC50 of 135 nM in A549 cells, selectively inhibits NRF2 activity in tumor cells. |
