Chemical Structure : UD-051
CAS No.:
2565713-51-9
UD-051
Catalog No.: PC-24918Not For Human Use, Lab Use Only.
UD-051 is a potent Nrf2 activator and inhibitor of Kelch-like ECH-associated protein 1 (Keap1) and Nrf2 interaction, activates NQO1 in Hepa1c1c7 cells with EC50 of 0.36 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UD-051 is a potent Nrf2 activator and inhibitor of Kelch-like ECH-associated protein 1 (Keap1) and Nrf2 interaction, activates NQO1 in Hepa1c1c7 cells with EC50 of 0.36 nM.
UD-051 significantly ameliorated the progressive phenotype of Alport syndrome mouse model in an Nrf2-dependent manner。
UD-051 suppressed tubular injury, including oxidative stress, inflammation, and dysregulated metabolism.
UD-051 with losartan, a renin-angiotensin system inhibitor that targets glomerular dysfunction, vastly ameliorated Alport kidney disease.
Physicochemical Properties
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M.Wt
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577.73
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Formula
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C35H39N5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3-dihydro-[1,4]oxazepino[7,6-g]quinolin-4(5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid
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References
1. Kaseda S, et al. Life Sci Alliance. 2025 Jun 17;8(8):e202503330.
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