CB5712809 | Keap1 inhibitor | Probechem Biochemicals

Chemical Structure : CB5712809

CB5712809 (CB 5712809)

Catalog No.: PC-24785Not For Human Use, Lab Use Only.

CB5712809 is a high affinity Keap1 inhibitor, inhibits Keap1:Nrf2 activity with IC50 of 36.7 nM.

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Biological Activity

CB5712809 is a high affinity Keap1 inhibitor, inhibits Keap1:Nrf2 activity with IC50 of 36.7 nM.
CB5712809 demonstrates a GI50 value of 4851 nM in inhibiting CCD 841 cell proliferation.
CB5712809 inhibits the proliferation of HCT116 and Caco-2 cells with GI50 values of 40.07 nM and 102.8 nM respectively.
CB5712809 upregulates SQSTM1/p62, and Nrf2, and downregulate Keap1 levels in CRC cells.

Physicochemical Properties

M.Wt	327.34
Formula	C20H13N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1H-benzimidazol-2-ylmethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

References

1. Dera AA, et al. Discov Oncol. 2025 Jun 1;16(1):981.

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CB5712809 (CB 5712809)

Biological Activity

Physicochemical Properties

References

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