Catalog No.: PC-42172Not For Human Use, Lab Use Only.
TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo.
TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo.
TBHQ ameliorates the doxorubicin-induced oxidative stress and apoptosis, increases the nuclear accumulation of Nrf2 and the Nrf2-regulated gene expression, including HO-1 and NQO-1 expression.
TBHQ also ameliorates early brain injury after experimental subarachnoid emorrhage in mice by enhancing Nrf2-independent autophagy.
Physicochemical Properties
M.Wt
166.217
Formula
C10H14O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,4-Benzenediol, 2-(1,1-dimethylethyl)-
References
1. Lin H, et al. Mol Pharmacol. 2014 May;85(5):682-91.
2. Wang LF, et al. Am J Transl Res. 2015 Oct 15;7(10):1724-35.
3. Li T, et al. Neurochem Res. 2015 Sep;40(9):1829-38.
