| Cat. No. |
Product Name |
Information |
| PC-43044 |
14-3-3 inhibitor WS3
14-3-3 inhibitor, NRF2 inhibitor
|
14-3-3 inhibitor WS3 is a potent, allosteric inhibitor of 14-3-3 proteins, potently inhibits the NRF2-ARE signal with IC50 of 135 nM in A549 cells, selectively inhibits NRF2 activity in tumor cells. |
| PC-42917 |
CDDO-EA
Nrf2 activator
|
CDDO-EA (DDO ethyl amide, RTA405) is a potent Nrf2 activator that upregulates Nrf2 expression and resulted in translocation of Nrf2 into the nucleus. |
| PC-42916 |
Omaveloxolone
Nrf2 activator
|
Omaveloxolone (RTA-408, RTA408) is a potent Nrf2 activator that increases expression of Nrf2 target genes and decreases expression of inflammatory mediators. |
| PC-44663 |
CDDO-Im
PPAR agonist, Nrf2 activator
|
CDDO-Im (RTA-403) is a potent Nrf2 activator that elevates protein levels of Nrf2 and induces Nrf2/ARE signaling, also activates PPAR with Ki values of 232 and 344 nM for PPARα and PPARγ. |
| PC-45198 |
Ezetimibe
Nrf2 activator, NPC1L1 inhibitor
|
Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules. |
| PC-42172 |
TBHQ
Nrf2 activator
|
TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo. |
| PC-42187 |
ML385
NRF2 inhibitor
|
ML385 (ML-385) is a first-in-class small molecule inhibitor of NRF2 that binds to Neh1 DNA binding domain of NRF2 (IC50=1.9 uM) and inhibits the downstream target gene expression. |
| PC-28258 |
Sodium danshensu
Nrf2/HO-1 agonist, Calpain-2 inhibitor
|
Sodium danshensu (Sanshensu sodium, Salvianic acid A) is an orally active phenolic compound from Salvia miltiorrhiza within antioxidant, anti-inflammatory, and pro-angiogenesis effects, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway, reduces reactive oxygen species (ROS) production and upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway, also inhibits SARS-CoV-2 with EC50 of 0.97 uM, also directly inhibits calpain-2 (CAPN2). |
| PC-28257 |
Danshensu
Nrf2/HO-1 agonist, Calpain-2 inhibitor
|
Danshensu (Dan shen suan A, Salvianic acid A) is an orally active phenolic compound from Salvia miltiorrhiza within antioxidant, anti-inflammatory, and pro-angiogenesis effects, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway, reduces reactive oxygen species (ROS) production and upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway, also inhibits SARS-CoV-2 with EC50 of 0.97 uM, also directly inhibits calpain-2 (CAPN2). |
| PC-27682 |
Obacunone
PPARα activator, Nrf2 activator
|
Obacunone is a naturally occurring limonoid triterpenoid with potent anti-inflammatory and antioxidant effects, activates PPARα, activates the Nrf2 signaling pathway, blocks the interaction between Nrf2 and KEAP1, and suppresses Nrf2 ubiquitination and degradation. |
| PC-27621 |
Sinomenine
Keap1-Nrf2 inhibitor
|
Sinomenine is a natural alkaloid with potential anti-fibrotic activity, inhibits the binding of Keap1 to Nrf2, promotes the nuclear accumulation of Nrf2, induces upregulated expressions of Nrf2-dependent antioxidative genes. |
| PC-27017 |
Keap1-p-p62-IN-2
Nrf2 inhibitor, Keap1-p-p62 inhibitor
|
Keap1-p-p62-IN-2 is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.096 uM, >6-fold selectivity over inhibition of Keap1-Nrf2 interaction. |
