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Danshensu

Chemical Structure : Danshensu

CAS No.: 76822-21-4

Danshensu (Salvianic acid A)

Catalog No.: PC-28257Not For Human Use, Lab Use Only.

Danshensu (Dan shen suan A, Salvianic acid A) is an orally active phenolic compound from Salvia miltiorrhiza within antioxidant, anti-inflammatory, and pro-angiogenesis effects, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway, reduces reactive oxygen species (ROS) production and upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway, also inhibits SARS-CoV-2 with EC50 of 0.97 uM, also directly inhibits calpain-2 (CAPN2).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Danshensu (Dan shen suan A, Salvianic acid A) is an orally active phenolic compound from Salvia miltiorrhiza within antioxidant, anti-inflammatory, and pro-angiogenesis effects, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway, reduces reactive oxygen species (ROS) production and upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway, also inhibits SARS-CoV-2 with EC50 of 0.97 uM, also directly inhibits calpain-2 (CAPN2).

Physicochemical Properties

M.Wt 198.17
Formula C9H10O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoic acid

References

1. Chen Yu, et al. Biomed Pharmacother. 2021 Oct:142:111995.

2. Wei Wang, et al. Acta Pharmacol Sin. 2022 Apr;43(4):771-780.

3. V Bharath Kumar, et al. Front Endocrinol (Lausanne). 2020 Sep 30:11:568436.

4. Zhang X, et al. Br J Pharmacol. 2026 Aug 19. doi: 10.1111/bph.70644.

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