Keap1-p-p62-IN-2

Chemical Structure : Keap1-p-p62-IN-2

Catalog No.: PC-27017Not For Human Use, Lab Use Only.

Keap1-p-p62-IN-2 is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.096 uM, >6-fold selectivity over inhibition of Keap1-Nrf2 interaction.

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Biological Activity

Physicochemical Properties

M.Wt	589.70
Formula	C33H35NO7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(tert-butyl)phenyl)-2-((4-((N-(carboxymethyl)-2,4,6-trimethylphenyl)sulfonamido)naphthalen-1-yl)oxy)acetic acid

References

1. Patent WO2017124835 A1.

2. Ziquan Zhao, et al. J Med Chem. 2026 Jun 11;69(11):13141-13164.

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Keap1-p-p62-IN-2

Biological Activity

Physicochemical Properties

References

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