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AI-10-104

Chemical Structure : AI-10-104

CAS No.: 1881276-00-1

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AI-10-104 (RUNX-CBFβ inhibitor)

Catalog No.: PC-61299Not For Human Use, Lab Use Only.

AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays.
    AI-10-104 reduces RUNX transcriptional activity by interfering with the formation of the CBFβ/RUNX1 and/or CBFβ/RUNX3 heterodimers in T-ALL cells.
    AI-10-104 impairs the growth of human T-ALL cell lines and primary patient samples (GI50=2.4 uM).

    Physicochemical Properties

    M.Wt 309.248
    Formula C14H10F3N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3-methoxypyridin-2-yl)-5-(trifluoromethoxy)-1H-benzo[d]imidazole

    References

    1. Choi A, et al. Blood. 2017 Oct 12;130(15):1722-1733.

    2. Illendula A, et al. EBioMedicine. 2016 Jun;8:117-31.

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