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AI-10-49

Chemical Structure : AI-10-49

CAS No.: 1256094-72-0

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AI-10-49

Catalog No.: PC-45078Not For Human Use, Lab Use Only.

AI-10-49 is a potent (FRET IC50=260 nM) RUNX-CBFβ protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AI-10-49 is a potent (FRET IC50=260 nM) RUNX-CBFβ protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1.
AI-10-49 triggers selective cell death in primary inv(16) AML patient blasts.
AI-10-49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice.

Physicochemical Properties

M.Wt 660.5233
Formula C30H22F6N6O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 34 mg/mL
Chemical Name/SMILES

1H-Benzimidazole, 2,2'-[oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)-

References

1. Illendula A, et al. Science. 2015 Feb 13;347(6223):779-84.

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