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Chemical Structure : AI-10-49
CAS No.: 1256094-72-0
Catalog No.: PC-45078Not For Human Use, Lab Use Only.
A potent (FRET IC50=260nM) protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $120 | In stock | |
| 25 mg | $232 | In stock | |
| 50 mg | $392 | In stock | |
| 100 mg | $528 | In stock |
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A potent (FRET IC50=260 nM) protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1; triggers selective cell death in primary inv(16) AML patient blasts; restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice.
| M.Wt | 660.5233 | |
| Formula | C30H22F6N6O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
1H-Benzimidazole, 2,2'-[oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)- |
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1. Illendula A, et al. Science. 2015 Feb 13;347(6223):779-84.
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