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AI-2

Chemical Structure : AI-2

CAS No.: 1380107-92-5

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AI-2 (Nrf2 activator AI-2)

Catalog No.: PC-62430Not For Human Use, Lab Use Only.

Nrf2 activator AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1.

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    Biological Activity

    Nrf2 activator AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1.
    AI-2 exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1.
    AI-2 is an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.

    Physicochemical Properties

    M.Wt 342.779
    Formula C18H15ClN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl 4-chloro-2-oxo-1-(pyridin-4-ylmethyl)-1,2-dihydroquinoline-3-carboxylate

    References

    1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47.

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