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AIGM-2024-4

Chemical Structure : AIGM-2024-4

CAS No.: 2639816-12-7

AIGM-2024-4

Catalog No.: PC-28217Not For Human Use, Lab Use Only.

AIGM-2024-4 is a small molecule modulator of Y-Box Binding Protein-1 (YB-1, YBX-1) with MST KD of 1.24 uM, significantly reduces tumor growth in DMBA- induced rat mammary tumor model, accompanied by altered expression of YB-1 and tumor progression associated proteins, including HER2, EGFR, ERα, and Ki-67, together with increased E-cadherin expression.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AIGM-2024-4 is a small molecule modulator of Y-Box Binding Protein-1 (YB-1, YBX-1) with MST KD of 1.24 uM, significantly reduces tumor growth in DMBA- induced rat mammary tumor model, accompanied by altered expression of YB-1 and tumor progression associated proteins, including HER2, EGFR, ERα, and Ki-67, together with increased E-cadherin expression.

    Physicochemical Properties

    M.Wt 347.37
    Formula C21H17NO4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-2-(4-methoxyphenyl)-3-(5-oxopyrrolidin-2-yl)naphthalene-1,4-dione

    References

    1. Somasundaram M, et al. Appl Biochem Biotechnol. 2026 Apr;198(4):2526-2554.

    2. Somasundaram M, et al. Biomed Pharmacother. 2026 Sep 12;203:119910.

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