Catalog No.: PC-72704Not For Human Use, Lab Use Only.
AIMP2-DX2 inhibitor 1 (Compound 1) is a specific chemical probe that can inhibit the tumor-promoting interaction between AIMP2-DX2 and HSP70 (IC50=2.9 uM).
AIMP2-DX2 inhibitor 1 (Compound 1) is a specific chemical probe that can inhibit the tumor-promoting interaction between AIMP2-DX2 and HSP70 (IC50=2.9 uM).
Compound 1 showed no inhibition of PRKACA and PRKAR2A PPI at 100 uM.
Compound 1 suppressed DX2-dependent cell proliferation in a DX2-inducible system.
Compound 1 caused degradation of DX2 via inhibition of binding with HSP70.
Compound 1 inhibited of proliferation cells with the highest levels of DX2, H460 and H358 with IC50 of 0.97 and 1.29 uM, respectively, with no effect on cells with lowest level of DX2.
Compound 1 (5 and 10 mg/kg, i.p.) significantly reduced tumor size in a dose-dependent manner in vivo via a xenograft model using H460 cells, with little effect on body weight.
Physicochemical Properties
M.Wt
280.323
Formula
C18H16O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
ethyl (Z)-2-benzoyl-3-phenylacrylate
References
1. Dae Gyu Kim, et al. J Pharmacol Exp Ther. 2021 Dec;379(3):358-371.
