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AK306

Chemical Structure : AK306

CAS No.:

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AK306 (AK 306;AK-306)

Catalog No.: PC-35161Not For Human Use, Lab Use Only.

AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
    AK306 demonstrates broad spectrum activity against of cancer cell lines with total growth inhibition values ranging from ~25 nM to 25 uM.
    AK306 disrupts Aurora A localization, leading to the formation of multiple foci, induces a p53-dependent cell death, and centrosome disruption.

    Physicochemical Properties

    M.Wt 379.281
    Formula C19H20Cl2N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4-(3,5-dichlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone

    References

    1. Bond MJ, et al. Mol Cancer Res. 2018 May 16. pii: molcanres.0178.2018.

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