AKBA

Chemical Structure : AKBA

CAS No.: 67416-61-9

Catalog No.: PC-27499Not For Human Use, Lab Use Only.

AKBA is a bioactive boswellic acid found in frankincense and allosteric, specific inhibitor of methionine adenosyltransferase 2A (MAT2A) with MST Kd of 129 nM, shows anti-inflammatory and anti-cancer properties.

Packing	Price	Stock
10 mg	$78	In stock
25 mg	$128	In stock
50 mg	$198	In stock
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Biological Activity

AKBA is a bioactive boswellic acid found in frankincense and allosteric, specific inhibitor of methionine adenosyltransferase 2A (MAT2A) with MST Kd of 129 nM, shows anti-inflammatory and anti-cancer properties.
AKBA does not interact with MAT2B directly.
AKBA decreases level of S-adenosylmethionine (SAM) and SAM/SAH ratio, and reprogrammed one‑carbon metabolism in HaCaT cells.
AKBA inhibits proliferation of HaCaT cells with IC50 of 27.3 uM.
AKBA alleviates both CD18hypo and imiquimod-induced mouse models of psoriasis when applied systemically or topically.
AKBA inhibits the enzyme activity of methionine adenosine transferase 2A (MAT2A) and reprograms one-carbon metabolism in keratinocytes, which accounts for its repression of keratinocyte hyperproliferation.
AKBA moderately inhibits T helper 17 (Th17) cell differentiation.

Physicochemical Properties

M.Wt	512.73
Formula	C32H48O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-Acetoxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid

References

1. Jing Bai, et al. EBioMedicine. 2019 Jan:39:575-590.

2. Fangzhou Lou, et al. Br J Pharmacol. 2024 Apr;181(8):1290-1307.

AKBA

Biological Activity

Physicochemical Properties

References

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