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AKCI

Chemical Structure : AKCI

CAS No.: 669750-88-3

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AKCI (AURKC-IκBα interaction inhibitor)

Catalog No.: PC-60347Not For Human Use, Lab Use Only.

AKCI is a small-molecule inhibitor that blocks the Aurora C/IκBα interaction (IC50=24.9 uM) and exerts antitumor activity in MDA-MB-231 breast cancer cells.

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    Biological Activity

    AKCI is a small-molecule inhibitor that blocks the Aurora C/IκBα interaction (IC50=24.9 uM) and exerts antitumor activity in MDA-MB-231 breast cancer cells.
    AKCI induces G2/M cell-cycle arrest through modulation of the p53/p21/CDC2/cyclin B1 pathways, significantly inhibits MDA-MB-231 cell migration and invasion, as well as decreasing colony formation and tumor growth.
    AKCI decreases PMA-induced activation of NF-κB.

    Physicochemical Properties

    M.Wt 369.473
    Formula C19H27N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4,8-dimethyl-N-(5-(2-morpholinoethyl)-1,4,5,6-tetrahydro-1,3,5-triazin-2-yl)quinazolin-2-amine

    References

    1. Han EH, et al. Oncotarget. 2017 Jun 29;8(41):69691-69708.

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