Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AKCI
Catalog No.: PC-60347Not For Human Use, Lab Use Only.
AKCI is a small-molecule inhibitor that blocks the Aurora C/IκBα interaction (IC50=24.9 uM) and exerts antitumor activity in MDA-MB-231 breast cancer cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AKCI is a small-molecule inhibitor that blocks the Aurora C/IκBα interaction (IC50=24.9 uM) and exerts antitumor activity in MDA-MB-231 breast cancer cells.
AKCI induces G2/M cell-cycle arrest through modulation of the p53/p21/CDC2/cyclin B1 pathways, significantly inhibits MDA-MB-231 cell migration and invasion, as well as decreasing colony formation and tumor growth.
AKCI decreases PMA-induced activation of NF-κB.
| M.Wt | 369.473 | |
| Formula | C19H27N7O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Han EH, et al. Oncotarget. 2017 Jun 29;8(41):69691-69708.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
