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Chemical Structure : AKT inhibitor VIII
CAS No.: 612847-09-3
Catalog No.: PC-42550Not For Human Use, Lab Use Only.
AKT inhibitor VIII is a selective, allosteric Akt inhibitor with IC50 of 58/210 for Akt1/2 respectively.
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|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
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| 50 mg | Get quote | ||
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AKT inhibitor VIII is a selective, allosteric Akt inhibitor with IC50 of 58/210 for Akt1/2 respectively.
AKT inhibitor VIII shows weak activity for Akt3 (IC50=2.12 uM).
AKT inhibitor VIII inhibits basal and IGF stimulated Akt1 and Akt2 phosphorylation in mouse lung, with no effect on Akt3 phosphorylation.
| M.Wt | 551.6404 | |
| Formula | C34H29N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]- |
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1. Lindsley, et al. Bioorg. Med. Chem. Lett. (2005), 15(3), 761-764.
2. Romorini L, et al. Sci Rep. 2016 Oct 20;6:35660.
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