AKT inhibitor VIII |CAS:612847-09-3 Probechem Biochemicals

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Chemical Structure : AKT inhibitor VIII

CAS No.: 612847-09-3

AKT inhibitor VIII (AKTi-1/2)

Catalog No.: PC-42550Not For Human Use, Lab Use Only.

AKT inhibitor VIII is a selective, allosteric Akt inhibitor with IC50 of 58/210 for Akt1/2 respectively.

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10 mg	$188	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AKT inhibitor VIII is a selective, allosteric Akt inhibitor with IC50 of 58/210 for Akt1/2 respectively.
AKT inhibitor VIII shows weak activity for Akt3 (IC50=2.12 uM).
AKT inhibitor VIII inhibits basal and IGF stimulated Akt1 and Akt2 phosphorylation in mouse lung, with no effect on Akt3 phosphorylation.

Physicochemical Properties

M.Wt	551.6404
Formula	C34H29N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-

References

1. Lindsley, et al. Bioorg. Med. Chem. Lett. (2005), 15(3), 761-764.

2. Romorini L, et al. Sci Rep. 2016 Oct 20;6:35660.

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AKT inhibitor VIII (AKTi-1/2)

Biological Activity

Physicochemical Properties

References

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