AL-GDa62

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Chemical Structure : AL-GDa62

Catalog No.: PC-72537Not For Human Use, Lab Use Only.

AL-GDa62 is a specific inhibitor of TCOF1, ARPC5, and UBC9, inhibits SUMOylation at low micromolar concentrations.

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Biological Activity

AL-GDa62 is a specific inhibitor of TCOF1, ARPC5, and UBC9, inhibits SUMOylation at low micromolar concentrations.
AL-GDa62 preferentially induced apoptosis in CDH1–/– cells, and Cdh1–/– mammary and gastric organoids were significantly more sensitive to AL-GDa62 at low micromolar concentrations.
AL-GDa62 is a potential synthetic lethal lead for the treatment of gastric cancer.

Physicochemical Properties

M.Wt	393.506
Formula	C24H28FN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-fluorobenzyl)-2-methyl-6-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine

References

1. Luxenburger A, et al. J Med Chem. 2021 Dec 23;64(24):18114-18142.

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AL-GDa62

Biological Activity

Physicochemical Properties

References

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