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ALDH1A1 inhibitor CM37

Chemical Structure : ALDH1A1 inhibitor CM37

CAS No.: 896795-60-1

ALDH1A1 inhibitor CM37 (CM037)

Catalog No.: PC-49239Not For Human Use, Lab Use Only.

ALDH1A1 inhibitor CM37 is a selective and competitive inhibitor of ALDH1A1 with Ki of 300 nM, shows minimal inhibitory effects for ALDH1A2, ALDH1A3, ALDH2, or ALDH3A1 at 20 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ALDH1A1 inhibitor CM37 is a selective and competitive inhibitor of ALDH1A1 with Ki of 300 nM, shows minimal inhibitory effects for ALDH1A2, ALDH1A3, ALDH2, or ALDH3A1 at 20 uM.
CM37 reduced ovarian cancer cell proliferation as spheroids under low attachment growth conditions and the expression of stemness-associated markers (OCT4 and SOX2) in ALDH+ cells fluorescence-activated cell sorting (FACS)-sorted from cell lines and malignant OC ascites.
CM37 promoted DNA damage in OC cells, as evidenced by induction of γH2AX.
CM37 augmented intracellular ROS accumulation, which in turn led to increased DNA damage and reduced OC cell viability.

Physicochemical Properties

M.Wt 431.569
Formula C21H25N3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

ethyl 2-((4-oxo-3-(3-(pyrrolidin-1-yl)propyl)-3,4-dihydrobenzo[4,5]thieno[3,2-d]pyrimidin-2-yl)thio)acetate

References

1. Condello S., et al. Oncogene. 2015;34:2297–2308.

2. Nkechiyere G Nwani, et al. Cancers (Basel). 2019 Apr 8;11(4):502.

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