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ALDH1A3 inhibitor NR6

Chemical Structure : ALDH1A3 inhibitor NR6

CAS No.: 2703797-37-7

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ALDH1A3 inhibitor NR6

Catalog No.: PC-20209Not For Human Use, Lab Use Only.

ALDH1A3 inhibitor NR6 is a specific ALDH1A3 inhibitor with IC50 of 5.3 uM and Ki of 3.7 uM, high selective over ALDH1A1 and ALDH1A2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ALDH1A3 inhibitor NR6 is a specific ALDH1A3 inhibitor with IC50 of 5.3 uM and Ki of 3.7 uM, high selective over ALDH1A1 and ALDH1A2.
    ALDH1A3 inhibitor NR6 inhibits cell growth of ALDH1A3+ cell lines U87MG and HCT116 cells with EC50 of 0.378 and 0.648 nM, respectively, in MTT assays.
    ALDH1A3 inhibitor NR6 is strictly selective against the ALDH1A3 isoform in both U87MG and HCT116 cell lines, inducing apoptotic death.
    ALDH1A3 inhibitor NR6 reduces significantly the expression of ALDH1A3 in HCT116 and for U87MG cells, reduces migration and invasiveness in vitro.

    Physicochemical Properties

    M.Wt 295.35
    Formula C20H13N3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzonitrile

    References

    1. Edoardo L M Gelardi, et al. Cancers (Basel). 2021 Jan 19;13(2):356.

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