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Chemical Structure : ALG-097111
Catalog No.: PC-38708Not For Human Use, Lab Use Only.
ALG-097111 is a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease (3CLpro) with IC50 of 7 nM, without effect against human cathepsin L (IC50>10 uM).
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ALG-097111 is a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease (3CLpro) with IC50 of 7 nM, without effect against human cathepsin L (IC50>10 uM).
ALG-097111 also dispalys high selectivity against a panel of 44 receptors, 58 kinases (no inhibition was noted up to 10 μM) and 9 human proteases.
ALG-097111 inhibited replication of SARS-CoV-2 in A549 cells expressing the human ACE-2 receptor with an EC50 of 200 nM, with no cytotoxicity.
ALG-097111 demonstrated broad-spectrum anti-coronaviral activity against other human coronaviruses such as the alpha-coronavirus 229E and the beta-coronavirus OC43 (EC50=123 and 336 nM, respectively).
ALG-097111 exhibited robust and significant viral replication inhibition in the lungs of infected hamsters.
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10 mM in DMSO |
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1. Koen Vandyck, et al. Biochem Biophys Res Commun. 2021 May 28;555:134-139.
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