ALKBH5 inhibitor 20m

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Chemical Structure : ALKBH5 inhibitor 20m

CAS No.: 126067-60-5

Catalog No.: PC-38700Not For Human Use, Lab Use Only.

ALKBH5 inhibitor 20m is a potent, selective RNA m6A demethylase AlkB homolog 5 (ALKBH5) inhibitor with IC50 of 21 nM.

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5 mg	$298	In stock
10 mg	$458	In stock
25 mg	$758	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ALKBH5 inhibitor 20m is a potent, selective RNA m6A demethylase AlkB homolog 5 (ALKBH5) inhibitor with IC50 of 21 nM.
ALKBH5 inhibitor 20m exhibits high selectivity towards ALKBH5 versus FTO as well as other AlkB subfamily members (IC50>25 uM).
ALKBH5 inhibitor 20m could efficiently stabilize ALKBH5 and increase m6A level in intact cells.

Physicochemical Properties

M.Wt	270.211
Formula	C12H9F3N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid

References

1. ZhenFang, et al. European Journal of Medicinal Chemistry, 11 May 2022, 114446.

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