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ALKBH5 inhibitor 20m

Chemical Structure : ALKBH5 inhibitor 20m

CAS No.: 1505579-77-0

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ALKBH5 inhibitor 20m (ALKBH5-IN-3)

Catalog No.: PC-38700Not For Human Use, Lab Use Only.

ALKBH5 inhibitor 20m is a potent, selective RNA m6A demethylase AlkB homolog 5 (ALKBH5) inhibitor with IC50 of 21 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ALKBH5 inhibitor 20m is a potent, selective RNA m6A demethylase AlkB homolog 5 (ALKBH5) inhibitor with IC50 of 21 nM.
ALKBH5 inhibitor 20m exhibits high selectivity towards ALKBH5 versus FTO as well as other AlkB subfamily members (IC50>25 uM).
ALKBH5 inhibitor 20m could efficiently stabilize ALKBH5 and increase m6A level in intact cells.

Physicochemical Properties

M.Wt 272.18
Formula C11H7F3N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-hydroxy-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid

References

1. Fang Z, et al. Eur J Med Chem. 2022. PMID: 35597008

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