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AM-0902

Chemical Structure : AM-0902

CAS No.: 1883711-97-4

AM-0902 (AMG0902;AM0902)

Catalog No.: PC-61124Not For Human Use, Lab Use Only.

AM-0902 (AMG0902) is a potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM).

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Biological Activity

AM-0902 (AMG0902) is a potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM).
AM-0902 (AMG0902) shows good selectivity over other TRP channels, including human TRPV1 and TRPV4, rat TRPV1, TRPV3, and TRPM8 (IC50>10 uM).
AM-0902 (AMG0902) demonstrates dose-dependent inhibition of AITC-induced flinching in rats.

Physicochemical Properties

M.Wt 370.797
Formula C17H15ClN6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one

References

1. Schenkel LB, et al. J Med Chem. 2016 Mar 24;59(6):2794-809.

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