Catalog No.: PC-20082Not For Human Use, Lab Use Only.
AM251 (AM 251) is a potent, selective CB1 receptor antagonist (inverse agonist) with IC50 of 8 nM, Ki of 7.49 nM, displays 306-fold selectivity over CB2 receptors.
AM251 (AM 251) is a potent, selective CB1 receptor antagonist (inverse agonist) with IC50 of 8 nM, Ki of 7.49 nM, displays 306-fold selectivity over CB2 receptors.
AM251 also is a potent GPR55 agonist (EC50=39 nM) and μ-opioid receptor antagonist (Ki=251 nM).
AM251 blocked the WIN 55,212-2-induced inhibition of evoked Iinhibitory postsynaptic currents (IPSCs).
Pretreatment with AM 251 (3 mg kg(-1)) antagonized the pressor and vasoconstrictor effects of HU 210 and WIN-55212-2 in conscious rats.
