AM404 is a seletive inhibitor of anandamide transport with IC50 of 2.2 uM, does not activate cannabinoid receptors or inhibit anandamide hydrolysis. AM404 prevents [3H]anandamide uptake in vitro and enhances various effects of anandamide administration both in vitro and in vivo. AM404 (10 mg/kg, i.v.) significantly potentiated and prolonged vasodepressor responses to anandamide in anesthesized guinea pigs.
Physicochemical Properties
M.Wt
395.59
Formula
C26H37NO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(4-hydroxyphenyl)-arachidonamide
References
1. Zygmunt PM, et al. Eur J Pharmacol. 2000 May 12;396(1):39-42.
2. Calignano A, et al. Eur J Pharmacol. 1997 Oct 15;337(1):R1-2.
3. Beltramo M, et al. Science. 1997 Aug 22;277(5329):1094-7.
4. Piomelli D, et al. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5802-7.
