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Chemical Structure : AM6545
Catalog No.: PC-20077Not For Human Use, Lab Use Only.
AM6545 (AM-6545) is a potent, selective, oral bioavailable and non-brain-penetrant neutral CB1R antagonist with Ki of 3.3 nM, >100-fold selectivity over CB2R.
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AM6545 (AM-6545) is a potent, selective, oral bioavailable and non-brain-penetrant neutral CB1R antagonist with Ki of 3.3 nM, >100-fold selectivity over CB2R.
Unlike rimonabant, AM6545 does not reduce GTPγS binding in mouse brain membranes and is therefore a neutral antagonist.
AM6545 (10 mg/kg/d for 28 days, oral) improved the metabolic profile in mice with diet-induced obesity (DIO).
AM6545 exhibited therapeutically relevant efficacy in reducing weight and improving hormonal/metabolic abnormalities in animal models of obesity.
AM6545 (4.0, 8.0 and 16.0 mg/kg, i.p.) significantly reduced food-reinforced operant responding in vivo.
| M.Wt | 556.46 | |
| Formula | C26H23Cl2N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tam J, et al. J Clin Invest. 2010 Aug;120(8):2953-66.
2. Randall PA, et al. Pharmacol Biochem Behav. 2010 Nov;97(1):179-84.
3. Limebeer CL, et al. Br J Pharmacol. 2010 Sep;161(2):336-49.
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