Catalog No.: PC-20077Not For Human Use, Lab Use Only.
AM6545 (AM-6545) is a potent, selective, oral bioavailable and non-brain-penetrant neutral CB1R antagonist with Ki of 3.3 nM, >100-fold selectivity over CB2R.
AM6545 (AM-6545) is a potent, selective, oral bioavailable and non-brain-penetrant neutral CB1R antagonist with Ki of 3.3 nM, >100-fold selectivity over CB2R.
Unlike rimonabant, AM6545 does not reduce GTPγS binding in mouse brain membranes and is therefore a neutral antagonist.
AM6545 (10 mg/kg/d for 28 days, oral) improved the metabolic profile in mice with diet-induced obesity (DIO).
AM6545 exhibited therapeutically relevant efficacy in reducing weight and improving hormonal/metabolic abnormalities in animal models of obesity.
AM6545 (4.0, 8.0 and 16.0 mg/kg, i.p.) significantly reduced food-reinforced operant responding in vivo.
