Catalog No.: PC-72103Not For Human Use, Lab Use Only.
AM9053 (AM 9053) is a potent, selective inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 30 nM, with limited effect on FAAH activity (IC50>100 uM).
AM9053 (AM 9053) is a potent, selective inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 30 nM, with limited effect on FAAH activity (IC50>100 uM).
AM9053 impacted CRC growth and development in vivo, altered the protein expression levels of Erb-B1, Erb-B2, Erb-B3 and AREG in tumour secretomes in treated xenograft mice.
AM9053 inhibited tumoural cell proliferation via TRPV1 and PPAR-α, promotes cell cycle arrest in the S phase and reduces cell migration, significantly decreased the migration of HCT116 and Caco-2 cells, NAAA knock-down mirrored the effects of NAAA inhibition with AM9053.
AM9053 increased PEA levels in the colon and prevents TNBS-induced colitis, also decreased the expression of proinflammatory cytokines (IL-1β, IL-12, and TNF-α) in the colon.
Physicochemical Properties
M.Wt
275.454
Formula
C17H25NS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(10-isothiocyanatodecyl)benzene
References
1. Barbara Romano, et al. Br J Pharmacol. 2021 Nov 17.
2. Alhouayek M, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):474-484.
3. Toma W, et al. Eur J Pain. 2021 Jul;25(6):1367-1380.
4. Mireille Alhouayek, et al. FASEB J. 2015 Feb;29(2):650-61.
