Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AM9053
Catalog No.: PC-72103Not For Human Use, Lab Use Only.
AM9053 (AM 9053) is a potent, selective inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 30 nM, with limited effect on FAAH activity (IC50>100 uM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AM9053 (AM 9053) is a potent, selective inhibitor of N-Acylethanolamine acid amidase (NAAA) with IC50 of 30 nM, with limited effect on FAAH activity (IC50>100 uM).
AM9053 impacted CRC growth and development in vivo, altered the protein expression levels of Erb-B1, Erb-B2, Erb-B3 and AREG in tumour secretomes in treated xenograft mice.
AM9053 inhibited tumoural cell proliferation via TRPV1 and PPAR-α, promotes cell cycle arrest in the S phase and reduces cell migration, significantly decreased the migration of HCT116 and Caco-2 cells, NAAA knock-down mirrored the effects of NAAA inhibition with AM9053.
AM9053 increased PEA levels in the colon and prevents TNBS-induced colitis, also decreased the expression of proinflammatory cytokines (IL-1β, IL-12, and TNF-α) in the colon.
| M.Wt | 275.454 | |
| Formula | C17H25NS | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Barbara Romano, et al. Br J Pharmacol. 2021 Nov 17.
2. Alhouayek M, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):474-484.
3. Toma W, et al. Eur J Pain. 2021 Jul;25(6):1367-1380.
4. Mireille Alhouayek, et al. FASEB J. 2015 Feb;29(2):650-61.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
