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AMD3100

Chemical Structure : AMD3100

CAS No.: 110078-46-1

AMD3100 (Plerixafor, JM-3100, AMD-3100, SID-791)

Catalog No.: PC-42164Not For Human Use, Lab Use Only.

Plerixafor (AMD3100) is a potent, selective CXCR4 inhibitor (IC50=44 nM) that inhibits the replication of various HIV-1 and HIV-2 strains in various cell lines with EC50 of 10ng/ml.

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Biological Activity

Plerixafor (AMD3100) is a potent, selective CXCR4 inhibitor (IC50=44 nM) that inhibits the replication of various HIV-1 and HIV-2 strains in various cell lines with EC50 of 10ng/ml.
Plerixafor (AMD3100) can produce mesenchymal stem cells and endothelial progenitor cells in mice in combination with VEGF.
Plerixafor (AMD3100) also is an allosteric agonist of CXCR7.

Physicochemical Properties

M.Wt 502.782
Formula C28H54N8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-

References

1. Zabel BA, et al. J Immunol. 2009, 183(5), 3204-3211.

2. De Clercq E, et al. Antimicrob Agents Chemother. 1994 Apr;38(4):668-74.

3. Pitchford SC, et al. Cell Stem Cell. 2009 Jan 9;4(1):62-72.

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