Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AMD3465
CAS No.: 185991-07-5
Catalog No.: PC-49202Not For Human Use, Lab Use Only.
AMD3465 (AMD 3465) is a potent, selective monomacrocyclic CXCR4 antagonist with IC50 of 0.75 nM for inhibition of 12G5 mAb binding to CXCR4, dose-dependently inhibits CXCL12 binding in SupT1 cells with IC50 of 18 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | $488 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AMD3465 (AMD 3465) is a potent, selective monomacrocyclic CXCR4 antagonist with IC50 of 0.75 nM for inhibition of 12G5 mAb binding to CXCR4, dose-dependently inhibits CXCL12 binding in SupT1 cells with IC50 of 18 nM.
AMD3465 inhibits CXCL12-induced calcium signaling in SupT1 cells with IC50 of 17 nM, AMD3465 is >10-fold more potent than AMD3100 in inhibiting calcium mobilization with IC50 of 4 and 58 nM, respectively.
AMD3465 completely failed to block the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78b and MIP-1b in U87.CD4.CCR5 cells.
AMD3465 dose-dependently inhibits intracellular calcium signaling, chemotaxis, CXCR4 endocytosis and mitogen-activated protein kinase phosphorylation induced by CXCL12.
AMD3465 is highly potent against X4 HIV strains (IC50=1-10 nM).
AMD3465 specifically blocks the interaction of HIV gp120 with CXCR4.
| M.Wt | 896.082 | |
| Formula | C24H44Br6N6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1-(pyridin-2-yl)methanamine hexahydrobromide |
|
1. Hatse S, et al. Biochem Pharmacol. 2005 Sep 1;70(5):752-61.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
