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AMPK activator 13

Chemical Structure : AMPK activator 13

CAS No.: 1243184-62-4

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AMPK activator 13 (AMPK-Activator-13)

Catalog No.: PC-60202Not For Human Use, Lab Use Only.

AMPK activator 13 is a potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AMPK activator 13 is a potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM).
    AMPK activator 13 inhibits de novo lipogenesis in cellular and animal models of hyperlipidemia.
    AMPK activator 13 the cell-permeable prodrug of compound 2 (AMPK-Activator-2).

    Physicochemical Properties

    M.Wt 431.334
    Formula C17H22NO10P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (((5-(5-oxo-4,5-dihydroisoxazol-3-yl)furan-2-yl)phosphoryl)bis(oxy))bis(methylene) bis(2-methylpropanoate)

    References

    1. Hunter RW, et al. Chem Biol. 2014 Jul 17;21(7):866-79.

    2. Gómez-Galeno JE, et al. ACS Med Chem Lett. 2010 Aug 30;1(9):478-82.

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