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AMPK activator 991

Chemical Structure : AMPK activator 991

CAS No.: 1219739-95-3

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AMPK activator 991

Catalog No.: PC-35496Not For Human Use, Lab Use Only.

AMPK activator 991 is an allosteric AMPK activator, activates non-phosphorylated Thr172 AMPK in vitro, binds to α1β1γ1 and α2β1γ1 with Kd of 0.13 and 0.17 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AMPK activator 991 is an allosteric AMPK activator, activates non-phosphorylated Thr172 AMPK in vitro, binds to α1β1γ1 and α2β1γ1 with Kd of 0.13 and 0.17 uM, respectively.

    Physicochemical Properties

    M.Wt 431.876
    Formula C24H18ClN3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-((5-chloro-6-(1-methyl-1H-indol-6-yl)-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid

    References

    1. Willows R, et al. Biochem J. 2017 Aug 22;474(17):3059-3073.

    2. Ngoei KRW, et al. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9.

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