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AMZ30

Chemical Structure : AMZ30

CAS No.: 1313613-09-0

AMZ30 (AMZ-30)

Catalog No.: PC-43242Not For Human Use, Lab Use Only.

AMZ30 is a potent, selective, covalent inhibitor of the serine hydrolase protein phosphatase methylesterase-1 (PME-1) with IC50 of 0.6 uM, >100-fold selectivity over other SHs.

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Biological Activity

AMZ30 is a potent, selective, covalent inhibitor of the serine hydrolase protein phosphatase methylesterase-1 (PME-1) with IC50 of 0.6 uM, >100-fold selectivity over other SHs.
AMZ30 selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells (IC50=3.5 uM in HEK 293T cells).
AMZ30 is a valuable pharmacological probe to study the role of methylation in regulating PP2A function.

Physicochemical Properties

M.Wt 461.4435
Formula C19H12FN3O6S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Propenenitrile, 2-[(4-fluorophenyl)sulfonyl]-3-[1-[(3-nitrophenyl)sulfonyl]-1H-pyrrol-2-yl]-, (2E)-

References

1. Bachovchin DA, et al. J Med Chem. 2011 Jul 28;54(14):5229-36.

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