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AN-329

Chemical Structure : AN-329

CAS No.: 882582-26-5

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AN-329 (AN-329/43448068)

Catalog No.: PC-23158Not For Human Use, Lab Use Only.

AN-329/43448068 (AN-329) is a small molecule inhibitor of Hsp110-STAT3 association, effectively inhibits HPAECs proliferation with IC50 of 22.67 uM, binds to bind to Hsp110 with KD of 12.6 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AN-329/43448068 (AN-329) is a small molecule inhibitor of Hsp110-STAT3 association, effectively inhibits HPAECs proliferation with IC50 of 22.67 uM, binds to bind to Hsp110 with KD of 12.6 uM.
    AN-329/43448068 reduces the expression of p-STAT3 and c-Myc, inhibits hypoxia-induced proliferation and migration of HPAECs.
    AN-329/43448068 effectively ameliorated hypoxia-induced PAH in rats.
    AN-329/43448068 inhibited Hsp110-STAT3 signaling pathway in hypoxia-induced PAH rats.

    Physicochemical Properties

    M.Wt 445.58
    Formula C23H31N3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(isopentyloxy)-N-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)benzamide

    References

    1. Congke Zhao, et al. Eur J Med Chem. 2024 Sep 7:279:116855.

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