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AP736

Chemical Structure : AP736

CAS No.: 1365531-21-0

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AP736 (AP 736)

Catalog No.: PC-21492Not For Human Use, Lab Use Only.

AP736 is a damantyl benzylbenzamide derivative with anti-melanogenic effects in melanocytes in vitro, acts via the downregulation of tyrosinase, TRP-1 and MITF expression.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AP736 is a damantyl benzylbenzamide derivative with anti-melanogenic effects in melanocytes in vitro, acts via the downregulation of tyrosinase, TRP-1 and MITF expression.
AP736 inhibits key melanogenic enzymes and the suppression of PKA-CREB signaling pathway.
AP736 markedly inhibits intracellular tyrosinase activity in the α-MSH-stimulated B16F10 melanoma cells.
AP736 does not directly inhibit tyrosinase activity.
AP736 induces GSK3β phosphorylation and reduces the MITF protein level.

Physicochemical Properties

M.Wt 437.54
Formula C26H31NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(adamantan-1-yl)-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide

References

1. Lee CS, et al. Exp Dermatol. 2013 Nov;22(11):762-4.

2. Shin HJ, et al. Int J Mol Med. 2015 Nov;36(5):1353-60.

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