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Chemical Structure : APR-246
CAS No.: 5291-32-7
Catalog No.: PC-62406Not For Human Use, Lab Use Only.
APR-246 (Eprenetapopt, PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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APR-246 (Eprenetapopt, PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
APR-246 (Eprenetapopt, PRIMA-1MET) also restores the pro-apoptotic function to mutant TAp63γ and TAp73β in tumor cells but has less effect on TAp73α.
APR-246 (Eprenetapopt, PRIMA-1MET) induces mutant p53-dependent mitochondria-mediated apoptosis through activation of caspase-2 with subsequent cytochrome c release and further activation of downstream caspase-9 and caspase-3.
APR-246 (Eprenetapopt, PRIMA-1MET) inhibits tumor xenograft growth in vivo.
| M.Wt | 199.25 | |
| Formula | C10H17NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one |
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1. Shen J, et al. Oncogene. 2008 Nov 20;27(51):6571-80.
2. Bykov VJ, et al. Oncogene. 2005 May 12;24(21):3484-91.
3. Rökaeus N, et al. Oncogene. 2010 Dec 9;29(49):6442-51.
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