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Chemical Structure : APX-115 freebase
CAS No.: 1270084-92-8
Catalog No.: PC-60409Not For Human Use, Lab Use Only.
Isuzinaxib (APX-115, Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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Isuzinaxib (APX-115, Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.
APX-115 shows no inhibitory activities on xanthine oxidase and glucose oxidase.
APX-115 inhibits the responses of BMMs to RANKL, including ROS generation, activation of MAPK and NF-κB, and osteoclast cells differentiation.
APX-115 protects db/db mice from renal injury.
| M.Wt | 279.343 | |
| Formula | C17H17N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-phenyl-1-(pyridin-2-yl)-4-propyl-1-5-hydroxypyrazol |
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1. Cha JJ, et al. Lab Invest. 2017 Apr;97(4):419-431.
2. Kwon G, et al. Oncotarget. 2017 Jun 16. doi: 10.18632/oncotarget.18540.
3. Joo JH, et al. Sci Rep. 2016 Mar 15;6:22389.
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