| Cat. No. |
Product Name |
Information |
| PC-49686 |
NCATS-SM7270
NOX2 inhibitor
|
NCATS-SM7270 is a specific small molecule NADPH oxidase 2 (NOX2) inhibitor with IC50 of 2.1 uM (Polymorphonuclear leukocytes, PMN), inhibits NOX2 in primary human and mouse granulocytes. |
| PC-49019 |
TIPTP
p22phox inhibitor
|
TIPTP is a highly potent and selective inhibitor of p22phox, inhibits the p22phox-Rubicon interaction with IC50 of 0.1 uM, and suppresses ROS-mediated inflammation. |
| PC-47046 |
GLX481304
Nox2/Nox4 inhibitor
|
GLX481304 is a specific small molecule inhibitor of Nox2 and Nox4 with IC50 values of 1.25 uM, shows negligible effects on Nox1. |
| PC-38850 |
LMH001
NOX2 inhibitor, p47phox-p22phox inhibitor
|
LMH001 is a small chemical compound blocking phosphorylated p47phox interaction with p22phox, inhibits effectively angiotensin II (AngII)-induced endothelial Nox2 activation and superoxide production (IC50=0.25 uM). |
| PC-73003 |
NOS31
Nox1 inhibitor
|
NOS31 is a potent, selective NADPH oxidase 1 (Nox1) inhibitor with IC50 of 2.0 uM. |
| PC-73002 |
GLX481372
Nox4/5 inhibitor
|
GLX481372 is a potent, selective NADPH oxidase 4 and 5 (Nox4 and Nox5) selective inhibitor with IC50 of 0.68 and 0.57 uM, respectively. |
| PC-72722 |
Diphenyleneiodonium chloride
GPR3 agonist
|
Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and potent, irreversible iNOS/eNOS inhibitor, also is an agonist of GPR3 with weak or no cross-reactivity with other GPCRs. |
| PC-36153 |
ML090
NOX1 inhibitor
|
ML090 (ML-090, CCG-44699, Fluoflavin, NSC 179821) is a potent, selecitve inhibitor of NADPH oxidase 1 (NOX1) with IC50 of 90 nM, displays no significant activities against NOX2, 3 and 4 (IC50>10 uM). |
| PC-35364 |
GLX351322
Nox4 inhibitor
|
GLX351322 (GLX-351322) is a novel potent inhibitor of NADPH oxidase 4 (Nox4), inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM. |
| PC-42961 |
GKT137831
NOX1/4 inhibitor
|
GKT137831 (Setanaxib, GKT-137831) is a potent, selective, dual NADPH oxidase Nox1/4 inhibitor with Ki of 110/140 nM, 15-fold less potent on Nox2 and 3-fold less potent on Nox5, and no affinity for xanthine oxidase. |
| PC-61657 |
Imipramine Blue
STAT5 inhibitor, NOX inhibitor
|
Imipramine Blue is a potent STAT5 inhibitor with a dual mechanism of action, potently inhibits STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition at 200-300 nM. |
| PC-60724 |
VAS-2870
NOX inhibitor
|
VAS2870 (VAS-2870) potent, specific NADPH oxidase (Nox) inhibitor, completely abolishes PDGF-mediated NAD(P)H oxidase activation and ROS production at 10-20 uM in vascular smooth muscle cells (VSMC). |
