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Chemical Structure : NCATS-SM7270
Catalog No.: PC-49686Not For Human Use, Lab Use Only.
NCATS-SM7270 is a specific small molecule NADPH oxidase 2 (NOX2) inhibitor with IC50 of 2.1 uM (Polymorphonuclear leukocytes, PMN), inhibits NOX2 in primary human and mouse granulocytes.
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NCATS-SM7270 is a specific small molecule NADPH oxidase 2 (NOX2) inhibitor with IC50 of 2.1 uM (Polymorphonuclear leukocytes, PMN), inhibits NOX2 in primary human and mouse granulocytes.
NCATS-SM7270 exhibited improved permeability, solubility, and half-life in rat microsomes, which retained similar activity against human neutrophil NOX2 and lower activity against xanthine oxidase compared to GSK2795039.
NCATS-SM7270 displayed no detectable activity against NOX3 and NOX4, and only marginal activity at the highest dose tested (about 100x the IC50 versus NOX2) against NOX1 and NOX5.
NCATS-SM7270 specifically inhibited NOX2 and had reduced inhibitory activity against xanthine oxidase in vitro.
NCATS-SM7270 protected mice from mild traumatic brain injury, partially reversed mild traumatic brain injury (mTBI) in NOX4KO mice.
| M.Wt | 446.53 | |
| Formula | C23H22N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hannah Mason, et al. Redox Biol. 2023 Jan 18;60:102611.
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