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NOS31

Chemical Structure : NOS31

CAS No.: 3035302-43-0

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NOS31 (Nox1 inhibitor NOS31)

Catalog No.: PC-73003Not For Human Use, Lab Use Only.

NOS31 is a potent, selective NADPH oxidase 1 (Nox1) inhibitor with IC50 of 2.0 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NOS31 is a potent, selective NADPH oxidase 1 (Nox1) inhibitor with IC50 of 2.0 uM.
    NOS31 inhibited ROS production in CaCO2 cells in a dose-dependent manner, inhibits NOXO1/NOXA1-induced ROS production.
    NOS31 is much less potent with other Nox enzymes Nox2, Nox3, Nox4, and Nox5 in HEK293 reconstitution systems (>15-fold selectivity).
    NOS31 inhibited the proliferation of several colon cancer cell lines in vitro (CaCO2, HT-29, DLD-1, RKO, and HCT-116), with no direct antioxidant activity nor cytotoxity.

    Physicochemical Properties

    M.Wt 472.541
    Formula C28H28N2O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1-hydroxy-3-(2-(2-(4-hydroxyphenyl)-6-methoxy-2,3-dihydrobenzofuran-3-yl)-1H-indol-3-yl)propan-2-yl)acetamide

    References

    1. Yamamoto T, et al. Biol Pharm Bull. 2018 Mar 1;41(3):419-426.

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