Chemical Structure : CRB-2131
CAS No.:
2834768-63-5
CRB-2131
(CRB2131)
Catalog No.: PC-25383Not For Human Use, Lab Use Only.
CRB-2131 is a potent small molecule inhibitor of NADPH oxidase (Nox) isozymes with IC50 values of 200-300 nM for human Nox1, Nox2, Nox4, Nox5, Duox1, and Duox2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CRB-2131 is a potent small molecule inhibitor of NADPH oxidase (Nox) isozymes with IC50 values of 200-300 nM for human Nox1, Nox2, Nox4, Nox5, Duox1, and Duox2.
CRB-2131 potently inhibits the Aβ-induced i) production of ROS by HT-22 mouse hippocampal neuronal cells (IC50 = 5.98 nM) and phosphorylation of Tau in the HT-22 neuronal cells, ROS production by BV2 microglial cells (IC50 = 17.1 nM), expression of TNF-α and IL-1β by BV2 microglial cells and BV2 microglial-cell migration (IC50 = 0.96 nM).
CRB-2131 inhibits ROS generation and Tau phosphorylation in 5XFAD mice, suppresses Tau phosphorylation and neuronal inflammation.
CRB-2131 (1-10 mpk) improves behavioral-test outcomes in 5XFAD mice, protects 5XFAD mice from mature neuron death and enhances the regeneration of immature neurons.
Physicochemical Properties
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M.Wt
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351.26
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Formula
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C16H9F4N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-fluoro-N-(5-phenyl-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide
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References
1. Lee J, et al. Adv Sci (Weinh). 2025 Aug 18:e05495.
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