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Chemical Structure : LMH001
Catalog No.: PC-38850Not For Human Use, Lab Use Only.
LMH001 is a small chemical compound blocking phosphorylated p47phox interaction with p22phox, inhibits effectively angiotensin II (AngII)-induced endothelial Nox2 activation and superoxide production (IC50=0.25 uM).
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LMH001 is a small chemical compound blocking phosphorylated p47phox interaction with p22phox, inhibits effectively angiotensin II (AngII)-induced endothelial Nox2 activation and superoxide production (IC50=0.25 uM).
LMH001 showed no effect on peripheral leucocyte oxidative response to pathogens.
LMH001 (2.5 mg/kg/d, ip. once) showed no effect on control mice, but inhibited completely AngII infusion-induced excess ROS production in vital organs, hypertension, aortic walls inflammation and reduced incidences of aortic aneurysm.
| M.Wt | 290.271 | |
| Formula | C15H14O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lampson M Fan, et al. Redox Biol. 2022 May;51:102269. doi: 10.1016/j.redox.2022.102269.
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