Chemical Structure : GKT136901
CAS No.:
955272-06-7
GKT136901
(GKT-136901)
Catalog No. : PC-22018Not For Human Use, Lab Use Only.
GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase NOX1/4 with Ki values of 160 and 165 nM, respectively.
Packing Price Stock Quantity 10 mg $88 In stock 0 1 2 3 4 5 25 mg $138 In stock 0 1 2 3 4 5 50 mg $218 In stock 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-2201801
Biological Activity
GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase NOX1/4 with Ki values of 160 and 165 nM, respectively.
Physicochemical Properties
M.Wt
366.81
Formula
C19H15ClN4O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(2-chlorophenyl)-4-Methyl-5-(pyridin-2-ylMethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
References
1. Vendrov AE, et al. J Biol Chem. 2010 Aug 20;285(34):26545-57.
2. Schildknecht S, et al. Curr Med Chem. 2014;21(3):365-76.
3. Sedeek M, et al. Clin Sci (Lond). 2013 Feb;124(3):191-202.
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