Diphenyleneiodonium chloride | GPR3 agonist

Chemical Structure : Diphenyleneiodonium chloride

CAS No.: 4673-26-1

Diphenyleneiodonium chloride (DPI)

Catalog No.: PC-72722Not For Human Use, Lab Use Only.

Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and potent, irreversible iNOS/eNOS inhibitor, also is an agonist of GPR3 with weak or no cross-reactivity with other GPCRs.

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Biological Activity

Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and potent, irreversible iNOS/eNOS inhibitor, also is an agonist of GPR3 (EC50=1 uM) with weak or no cross-reactivity with other GPCRs.

Physicochemical Properties

M.Wt	314.55
Formula	C12H8ClI
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[1,1'-Biphenyl]-2,2'-diyliodonium chloride

References

1. Chenli Ye, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):437-43.

2. Ma W, et al. Nat Commun. 2022 Jan 26;13(1):529.

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Diphenyleneiodonium chloride (DPI)

Biological Activity

Physicochemical Properties

References

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