GLX481372 | Nox4/5 inhibitor | Probechem Biochemicals

Chemical Structure : GLX481372

GLX481372 (GLX 481372, GLX-481372)

Catalog No.: PC-73002Not For Human Use, Lab Use Only.

GLX481372 is a potent, selective NADPH oxidase 4 and 5 (Nox4 and Nox5) selective inhibitor with IC50 of 0.68 and 0.57 uM, respectively.

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Biological Activity

GLX481372 is a potent, selective NADPH oxidase 4 and 5 (Nox4 and Nox5) selective inhibitor with IC50 of 0.68 and 0.57 uM, respectively.
GLX481372 weakly inhibited NOX1 and NOX2 with IC50 of >7 uM.
GLX481372 reduced human islet ROS production in human islet cells.

Physicochemical Properties

M.Wt	403.534
Formula	C23H29N7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-(3,4-Dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine

References

1. Wang X, et al. PLoS One. 2018 Sep 28;13(9):e0204271.

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GLX481372 (GLX 481372, GLX-481372)

Biological Activity

Physicochemical Properties

References

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