| Cat. No. |
Product Name |
Information |
| PC-35364 |
GLX351322
Nox4 inhibitor
|
GLX351322 (GLX-351322) is a novel potent inhibitor of NADPH oxidase 4 (Nox4), inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM. |
| PC-42961 |
GKT137831
NOX1/4 inhibitor
|
GKT137831 (Setanaxib, GKT-137831) is a potent, selective, dual NADPH oxidase Nox1/4 inhibitor with Ki of 110/140 nM, 15-fold less potent on Nox2 and 3-fold less potent on Nox5, and no affinity for xanthine oxidase. |
| PC-61657 |
Imipramine Blue
STAT5 inhibitor, NOX inhibitor
|
Imipramine Blue is a potent STAT5 inhibitor with a dual mechanism of action, potently inhibits STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition at 200-300 nM. |
| PC-60724 |
VAS2870
NOX inhibitor
|
VAS2870 (VAS-2870) is a potent, specific NADPH oxidase (Nox) inhibitor, completely abolishes PDGF-mediated NAD(P)H oxidase activation and ROS production at 10-20 uM in vascular smooth muscle cells (VSMC). |
| PC-60723 |
ML171
NOX1 inhibitor
|
ML171 is a potent, specific, cell-active NADPH oxidase1 (Nox1) inhibitor that strongly blocks ROS generation in HT29 cells with IC50 of 0.129 uM. |
| PC-60410 |
APX-115
NADPH oxidase inhibitor
|
Isuzinaxib (APX-115, Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively. |
| PC-60409 |
APX-115 freebase
NADPH oxidase inhibitor
|
APX-115 freebase (Isuzinaxib, Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively. |
| PC-45569 |
GSK2795039
NOX2 inhibitor
|
GSK2795039 (GSK 2795039) is a potent and selective inhibitor of NOX2 (NADPH oxidase 2) with pIC50 of 6.57. |
| PC-27684 |
VAS3947
pan-NOX inhibitor
|
VAS3947 is a specific pan-NADPH oxidase (NOX) inhibitor with IC50 of 86.8, 5.6, 30.5 and 39.2 uM for NOX1, 2, 4 and 5 respectively. |
| PC-27679 |
NOX4 inhibitor 18
NOX4 inhibitor
|
NOX4 inhibitor 18 is a first-in-class homolog-selective, covalent NOX4 inhibitor with IC50 of 3.1 uM, IC50 app of 0.42 uM for NOX4 dehydrogenase domain, show no activity against NOX1,2,5 (IC50>100 uM). |
| PC-22988 |
Apocynin
NOX inhibitor
|
Apocynin is a selective NADPH oxidase (NOX) inhibitor with IC50 of 10 uM, shows potential anti-inflammatory and neurodegenerative activities. |
| PC-22018 |
GKT136901
NOX1/4 inhibitor
|
GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase NOX1/4 with Ki values of 160 and 165 nM, respectively. |
