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GLX7013114

Chemical Structure : GLX7013114

CAS No.:

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GLX7013114 (GLX-7013114)

Catalog No.: PC-73001Not For Human Use, Lab Use Only.

GLX7013114 (GLX-7013114) is a novel selective NADPH oxidase 4 (Nox4) inhibitor with IC50 of 0.3 uM in in CJ Nox4 HEK 293 cell asays.

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    Biological Activity

    GLX7013114 (GLX-7013114) is a novel selective NADPH oxidase 4 (Nox4) inhibitor with IC50 of 0.3 uM in in CJ Nox4 HEK 293 cell asays.
    GLX7013114 displays no activity against Nox 1/2/3/5, as well as Glucose oxidase and Xanthine oxidase; does not display any redox activity.
    GLX7013114 inhibits TGFβ-induced upregulation of mesenchymal genes.
    GLX7013114 protected islet cells against both cytokines and high glucose + palmitate.

    Physicochemical Properties

    M.Wt
    Formula
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Month
    Shipping
    Solubility

    Chemical Name/SMILES

    References

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