ML 171 is a potent, specific, cell-active NADPH oxidase1 (Nox1) inhibitor that strongly blocks ROS generation in HT29 cells with IC50 of 0.129 uM.
ML 171 shows only marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms.
ML 171 also blocks the ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells.
Physicochemical Properties
M.Wt
241.31
Formula
C14H11NOS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-Acetylphenothiazine
References
1. Gianni D, et al. ACS Chem Biol. 2010 Oct 15;5(10):981-93.
2. Martínez-Revelles S, et al. Antioxid Redox Signal. 2013 Jan 1;18(1):51-65.
3. Walsh TG, et al. Redox Biol. 2014 Jan 13;2:178-86.
4. Gianni D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
