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Chemical Structure : ML 171
CAS No.: 6631-94-3
Catalog No.: PC-60723Not For Human Use, Lab Use Only.
ML 171 is a potent, specific, cell-active NADPH oxidase1 (Nox1) inhibitor that strongly blocks ROS generation in HT29 cells with IC50 of 0.129 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $88 | In stock | |
| 200 mg | $128 | In stock | |
| 1 g | Get quote |
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ML 171 is a potent, specific, cell-active NADPH oxidase1 (Nox1) inhibitor that strongly blocks ROS generation in HT29 cells with IC50 of 0.129 uM.
ML 171 shows only marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms.
ML 171 also blocks the ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells.
| M.Wt | 241.31 | |
| Formula | C14H11NOS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Acetylphenothiazine |
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1. Gianni D, et al. ACS Chem Biol. 2010 Oct 15;5(10):981-93.
2. Martínez-Revelles S, et al. Antioxid Redox Signal. 2013 Jan 1;18(1):51-65.
3. Walsh TG, et al. Redox Biol. 2014 Jan 13;2:178-86.
4. Gianni D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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