| Cat. No. |
Product Name |
Information |
| PC-27683 |
MC4762
NOX2/MAOB inhibitor
|
MC4762 (Compound 9a) is a potent, dual covalent NOX2/MAOB inhibitor with IC50 of 0.155 uM, selectively inhibits monoamine oxidase B (MAOB over MAOA (465-fold) with IC50 of 0.182 uM. |
| PC-27680 |
NOX4-IN-1
NOX4 inhibitor
|
NOX4-IN-1 is a small molecule NOX4 inhibitor, shows efficacy in ameliorating fibrosis and inflammation. |
| PC-25383 |
CRB-2131
Nox inhibitor
|
CRB-2131 is a potent small molecule inhibitor of NADPH oxidase (Nox) isozymes with IC50 values of 200-300 nM for human Nox1, Nox2, Nox4, Nox5, Duox1, and Duox2. |
| PC-24326 |
NOXA1ds
NOX1 inhibitor
|
NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor with IC50 of 20 nM, potently inhibits Nox1-derived superoxide anion (O2·-) production with no effect on Nox2-, Nox4-, Nox5-, or xanthine oxidase-derived reactive oxygen species production. |
| PC-49686 |
NCATS-SM7270
NOX2 inhibitor
|
NCATS-SM7270 is a specific small molecule NADPH oxidase 2 (NOX2) inhibitor with IC50 of 2.1 uM (Polymorphonuclear leukocytes, PMN), inhibits NOX2 in primary human and mouse granulocytes. |
| PC-49019 |
TIPTP
p22phox inhibitor
|
TIPTP is a highly potent and selective inhibitor of p22phox, inhibits the p22phox-Rubicon interaction with IC50 of 0.1 uM, and suppresses ROS-mediated inflammation. |
| PC-47046 |
GLX481304
Nox2/Nox4 inhibitor
|
GLX481304 is a specific small molecule inhibitor of Nox2 and Nox4 with IC50 values of 1.25 uM, shows negligible effects on Nox1. |
| PC-38850 |
LMH001
NOX2 inhibitor, p47phox-p22phox inhibitor
|
LMH001 is a small chemical compound blocking phosphorylated p47phox interaction with p22phox, inhibits effectively angiotensin II (AngII)-induced endothelial Nox2 activation and superoxide production (IC50=0.25 uM). |
| PC-73003 |
NOS31
Nox1 inhibitor
|
NOS31 is a potent, selective NADPH oxidase 1 (Nox1) inhibitor with IC50 of 2.0 uM. |
| PC-73002 |
GLX481372
Nox4/5 inhibitor
|
GLX481372 is a potent, selective NADPH oxidase 4 and 5 (Nox4 and Nox5) selective inhibitor with IC50 of 0.68 and 0.57 uM, respectively. |
| PC-72722 |
Diphenyleneiodonium chloride
NOX inhibitor, GPR3 agonist
|
Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase (NOX) and potent, irreversible iNOS/eNOS inhibitor, also is an agonist of GPR3 (EC50=1 uM) with weak or no cross-reactivity with other GPCRs. |
| PC-36153 |
ML090
NOX1 inhibitor
|
ML090 (ML-090, CCG-44699, Fluoflavin, NSC 179821) is a potent, selecitve inhibitor of NADPH oxidase 1 (NOX1) with IC50 of 90 nM, displays no significant activities against NOX2, 3 and 4 (IC50>10 uM). |
